[ PAPER ] · 2017 · Journal of Cerebral Blood Flow and Metabolism
Implications of neurovascular uncoupling in functional magnetic resonance imaging (fMRI) of brain tumors
Rebecca W. Pak, Darian H. Hadjiabadi, J. Senarathna, S. Agarwal, N. Thakor, J. Pillai, A. Pathak
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[ TLDR ]
The physiology of the neurovascular unit is reviewed, how it is remodeled, and functionally altered by brain cancer cells, and how the suppression of anomalous tumor blood vessel formation with antiangiogenic therapies can “normalize” the brain tumor vasculature, and potentially restore neurov vascular coupling.