[ PAPER ] · 2018 · Nature reviews. Immunology
CD4+ T cell help in cancer immunology and immunotherapy
J. Borst, T. Ahrends, Nikolina Bąbała, C. Melief, W. Kastenmüller
No open-access PDF, so we'll narrate a briefing from the abstract instead.
[ TLDR ]
This Review highlights the cellular dynamics and membrane receptors that mediate CD4+ T cell help and the molecular mechanisms of the enhanced antitumour activity of CTLs and discusses the molecular nature of help signals and how they can be harnessed to improve cancer immunotherapy.