[ PAPER ] · 2024 · Journal of Experimental Medicine
Radiotherapy and immunology
Liangliang Wang, C. Lynch, S. Pitroda, András Piffkó, Kaiting Yang, Amy K Huser, H. Liang, R. Weichselbaum
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[ TLDR ]
Preclinical and clinical data related to the importance of immune responses to radiotherapy-induced anti-tumor effects, as well as blockade of immune checkpoints PD-1/PD-L1 and/or CTLA-4 in combination with radiotherapy are reviewed.
[ ABSTRACT ]
The majority of cancer patients receive radiotherapy. Wang et al. review preclinical and clinical data related to the importance of immune responses to radiotherapy-induced anti-tumor effects, as well as blockade of immune checkpoints PD-1/PD-L1 and/or CTLA-4 in combination with radiotherapy.